Mendeleev Commun.,
2012 , том 22, выпуск 2, страницы 73–74
(Mi mendc2743)
Эта публикация цитируется в
10 статьях
Rational design and synthesis of novel Syk-kinase inhibitors A. A. Zeifman a ,
I. Yu. Titov ab ,
I. Svitanko b ,
T. V. Rakitina cd ,
A. V. Lipkin de ,
V. S. Stroylov ab ,
O. V. Stroganov ab ,
F. N. Novikov a ,
G. G. Chilov ab a MolTech Ltd, Moscow, Russian Federation
b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation c M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation d National Research Centre 'Kurchatov Institute', Moscow, Russian Federation e A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russian Federation Аннотация:
Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7
H -pyrrolo[2,3-
d ]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC
50 = 230±10 nM
Язык публикации: английский
DOI:
10.1016/j.mencom.2012.03.006
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