I. V. Vystorop, N. P. Konovalova, T. E. Sashenkova, E. N. Berseneva, A. V. Chernyak, B. S. Fedorov, R. G. Kostyanovsky, “1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy”, Mendeleev Commun., 21:5 (2011), 239

Эта публикация цитируется в 5 статьях

1-Hydroxy-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one and its (±)-3-methyl homologue: regioselective synthesis and in vivo evaluation as adjuvants in leukemia chemotherapy

I. V. Vystorop^a, N. P. Konovalova^a, T. E. Sashenkova^a, E. N. Berseneva^a, A. V. Chernyak^a, B. S. Fedorov^a, R. G. Kostyanovsky^b

^a Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^b N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation

Аннотация: Condensation of glycine and dl-alanine hydroxamic acids with 1-methyl-4-piperidone regioselectively gave the corresponding titled spiro piperidine hydroxyimidazolidinones capable of enhancing sensitivity of P388 and L1210 leukemias in mice models to the known anticancer drugs cisplatin and cyclophosphamide.

Язык публикации: английский

DOI: 10.1016/j.mencom.2011.09.002

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