A. V. Ivachtchenko, P. M. Yamanushkin, O. D. Mitkin, O. I. Kiselev, “Bromination of indomethacin”, Mendeleev Commun., 20:2 (2010), 111

Эта публикация цитируется в 12 статьях

Bromination of indomethacin

A. V. Ivachtchenko^ab, P. M. Yamanushkin^a, O. D. Mitkin^a, O. I. Kiselev^c

^a Department of Organic Chemistry, Chemical Diversity Research Institute, Khimki, Moscow Region, Russian Federation
^b ChemDiv Inc., San Diego, CA, USA
^c A.A. Smorodintsev Research Institute of Influenza, St. Petersburg, Russian Federation

Аннотация: Treatment of indomethacin with N-bromosuccinimide in AcOH results in bromination in aromatic positions 4 and 6, while the use of tetrachloromethane allows ultimate bromination at the C(2) Me group of the indole moiety to proceed.

Язык публикации: английский

DOI: 10.1016/j.mencom.2010.03.016

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