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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2023, том 33, выпуск 2, страницы 221–224 (Mi mendc356)

Эта публикация цитируется в 3 статьях

Communications

Multi-compartment containers from a mixture of natural and synthetic lipids

A. A. Yaroslavova, A. A. Efimovaa, T. A. Abramovaa, D. V. Pozdyshevb, V. I. Muronetzb

a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b A.N. Belozersky Research Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation


Аннотация: Small anionic liposomes were electrostatically adsorbed on the surface of larger cationic liposomes thus forming multi- compartment complexes composed exclusively of natural and synthetic lipids. The complexes contained two dozen anionic liposomes per a single cationic liposome and showed low cytotoxicity and ability to enzyme-induced bio-degradation. The liposomal multi-compartment complexes demonstrate great application potential as containers for drug encapsulation and delivery.

Ключевые слова: liposome, multi-liposomal complex, multi-compartment container, biodegradation, cytotoxicity.

Язык публикации: английский

DOI: 10.1016/j.mencom.2023.02.023



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