S. V. Kurmaz, I. I. Ivanova, N. S. Emelyanova, D. V. Konev, V. A. Kurmaz, N. V. Filatova, A. A. Balakina, A. A. Terentiev, “Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate”, Mendeleev Commun., 33:2 (2023), 255

Эта публикация цитируется в 3 статьях

Communications

Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate

S. V. Kurmaz^a, I. I. Ivanova^a, N. S. Emelyanova^a, D. V. Konev^a, V. A. Kurmaz^a, N. V. Filatova^a, A. A. Balakina^a, A. A. Terentiev^abc

^a Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^b Department of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c Moscow Region State Pedagogical University, Mytishi, Moscow Region, Russian Federation

Аннотация: Compositions of doxorubicin with a terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate have been prepared and investigated by UV-VIS and NMR spectroscopy, cyclic voltammetry and DFT quantum chemical modeling. Oxygen containing groups of the terpolymer and hydrogen atoms of the drug OH and NH⁺ groups form hydrogen bonds. The compositions have lower cytotoxicity in vitro compared with that of free doxorubicin

Ключевые слова: N-vinylpyrrolidone, triethylene glycol dimethacrylate, terpolymer, doxorubicin, quantum chemical modeling, cyclic voltammetry, cytotoxicity.

Язык публикации: английский

DOI: 10.1016/j.mencom.2023.02.034

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