Influence of the nucleophile structure on the selectivity of the nitro group and fluorine displacement in SNAr reactions

Temperature-dependent measurements according to the modified Eyring equation allowed the evaluation of the displacement selectivity of the nitro group and fluorine in the S_NAr reactions of 3-nitro-5-R-benzotrifluorides (R = NO₂, F) with the nucleophiles (2ArYH)·K₂CO₃ and ArY−K⁺ (Y = O, S) in DMF solutions.