Stereospecific intramolecular cyclization of diethyl (R)-2-(N-benzylidene)-aminobutyl phosphite into (3R,5R)-2-ethoxy-2-oxo-3-phenyl-5-ethyl-1,4,2-oxazaphosphorinane in the presence of hydrogen chloride
Аннотация:
Diethyl (R)-2-(N-benzylidene)aminobutyl phosphite, formed in reaction of (R)-(+)-2-(N-benzylidene)aminobutan-1-ol with diethyl chlorophosphite, undergoes stereospecific intramolecular cyclization to give P-epimeric (3R,5R)-2-ethoxy-2-oxo-3-phenyl-5-ethyl-1,4,2-oxazaphosphorinanes as final reaction products.