A facile synthesis of (±)-15-deoxy-Δ12,14-prostaglandin J2 methyl ester

A simple and facile synthesis of racemic 15-deoxy-Δ^12,14-prostaglandin J₂ methyl ester from readily available Corey lactone diol in total eleven steps was suggested. The standard methods provided a pathway to a block with an integrated w w w-chain and further to PGJ₂ methyl ester. The latter was smoothly converted to the target prostaglandin in the TsOH–CH₂Cl₂ medium when allylic alcohol moiety was transformed to exocyclic diene substituent conjugated with endocyclic enone system.