The differing reactivity of the bromo and nitro groups in 4-bromo-5-nitrophthalonitrile towards nucleophilic attack

The high reactivity of 4-bromo-5-nitrophthalonitrile and different mobilities of the leaving groups (bromo and nitro) in aromatic nucleophilic substitution reactions offer new opportunities for the synthesis of substituted phthalonitriles and then various heterocyclic compounds.