Sortase-promoted synthesis of homooligomers from a monomeric protein

We demonstrated covalent cross-linking of two or three protein molecules specifically at the C-terminus by sortase-catalyzed conjugation of recombinant proteins with conformationally rigid-flexible tetraantennary templates, where structure of the antenna is [Gly-Gly-(N-CH₂COOH)Gly]_nCH₂–.