A. A. Shalina, L. R. Idrisova, A. V. Nemtarev, T. I. Abdullin, V. F. Mironov, “Synthesis of 3-amino triterpenes involving the NaBH3CN/MoCl5 reduction of the oxime precursors”, Mendeleev Commun., 35:5 (2025), 521

Communications

Synthesis of 3-amino triterpenes involving the NaBH₃CN/MoCl₅ reduction of the oxime precursors

A. A. Shalina^a, L. R. Idrisova^a, A. V. Nemtarev^ab, T. I. Abdullin^a, V. F. Mironov^b

^a Kazan (Volga Region) Federal University, 420008 Kazan, Russian Federation
^b A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, 420088 Kazan, Russian Federation

Аннотация: A new efficient method for the preparation of 3-amino derivatives of pentacyclic lupane and germanicane triterpenoids, valuable precursors for the rational design of physiologically active agents, is presented. The key step involves the reduction of triterpenoid 3-oximes with sodium cyanoborohydride in the presence of molybdenum(v) chloride.

Ключевые слова: triterpenes, betulin, allobetulin, lupane type, molybdenum(v) chloride, reduction reaction, sodium cyanoborohydride, oximes, amines.

Поступила в редакцию: 07.02.2025
Принята в печать: 31.03.2025

Язык публикации: английский

DOI: 10.71267/mencom.7744

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