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ЖУРНАЛЫ // Mendeleev Communications // Архив
Mendeleev Commun., 2022, том 32, выпуск 5, страницы 594–596 (Mi mendc736)
Эта публикация цитируется в 3 статьях

Communications

Highly cytotoxic palladium(ii) complexes with 1,2,4-triazole-derived carbene ligands

V.-H. Nguyena, H. T. Phunga, D. T. Doana, T. T. Dob

a Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
b Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, Vietnam


Аннотация: Two novel palladium(ii) complexes, trans-[PdBr2(tz-Mes)2] and trans-[PdBr2(tz-Dipp)2] featuring less explored 1,2,4-triazole-derived N-heterocyclic carbene (tz) have been synthesized. In solution, they exist both as trans-syn and trans-anti rotamers while their syn/anti ratios can be determined by 1H NMR harnessing the built-in aromatic rings as NMR probes. Complex trans-[PdBr2(tz-Mes)2] is highly cytotoxic toward A549, MCF-7, LNCaP and HT-29 cancerous cells.

Ключевые слова: 1,2,4-triazolin-5-ylidene ligands, palladium(ii) complexes, palladium-NHC, anticancer activities, NMR probe.

Язык публикации: английский

DOI: 10.1016/j.mencom.2022.09.008


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