A. Yu. Bobrova, M. A. Novikov, R. A. Novikov, P. V. Dorovatovskii, A. D. Volodin, A. A. Korlyukov, Yu. V. Tomilov, “Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands”, Mendeleev Commun., 32:5 (2022), 619

Эта публикация цитируется в 3 статьях

Communications

Highly enantioselective amination of η³-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands

A. Yu. Bobrova^a, M. A. Novikov^a, R. A. Novikov^a, P. V. Dorovatovskii^b, A. D. Volodin^c, A. A. Korlyukov^c, Yu. V. Tomilov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
^c A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Аннотация: The key enantioselectivity-determining step in Pd-catalyzed asymmetric amination of 2-fluoroallylic substrates was optimized using model reaction of η³-(2-fluorocycloheptenyl)-palladium complexes bearing chiral P,P- and P,N-ligands with various amines. (S)-ButPHOX was found to be the most effective ligand allowing the formation of 2-fluoroallyl amines and anilines with high enantioselectivity.

Ключевые слова: fluoroalkenes, 2-fluoroallyl amines, enantioselective catalysis, chiral palladium complexes, allylic amination.

Язык публикации: английский

DOI: 10.1016/j.mencom.2022.09.016

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