Carboxymethylcellulose microgels with Bi3+ and Ru3+ for medical applications

The possibility of using carboxymethylcellulose as a platform for transporting ruthenium or bismuth ions in the body along with a medicinal preparation (a thiourea-derived NO synthase activator) was examined. Carboxymethylcellulose microgels were obtained by cross-linking with ruthenium or bismuth ions in a biological environment, and differences in their physicochemical parameters were identified. Furthermore, it was found that the size and aggregation stability of the microgels depend on the amount of the introduced organic ligand-drug.