K. S. Egorova, A. V. Posvyatenko, A. S. Galushko, A. E. Kolesnikov, “Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl”, Mendeleev Commun., 34:2 (2024), 181

Communications

Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl

K. S. Egorova^a, A. V. Posvyatenko^ab, A. S. Galushko^a, A. E. Kolesnikov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation

Аннотация: Using bio-Strips and cytotoxicity potentials, the least and most harmful substances involved in the synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl from 4-methoxyphenyl- boronic acid and aryl halide were identified. A total of 36 synthetic routes were analyzed.

Ключевые слова: C–C cross-coupling, 4-methoxy-4'-nitro-1,1'-biphenyl, toxicity, cytotoxicity, bio-Profile, bio-Strip, cytotoxicity potential.

Язык публикации: английский

DOI: 10.1016/j.mencom.2024.02.007

	*Дополнительные материалы:*
		Supplementary_data_1.pdf	2.3 Mb