Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids

Silatrane-1H-pyrrole-2-carboxamide hybrids conjugated via propane-1,3-diyl linker have been synthesized by the reaction of 1-(3-aminopropyl)silatrane with 2-(trichloroacetyl)pyrroles. Their in silico screening would predict their antitumor activity. Their in vitro screening for antimicrobial activity revealed the representative with R¹=R²=R³=H to be the most potent against Gram-positive microorganisms such as E. durans, B. subtilis and E. coli.