N. S. Temnyakova, D. A. Vasilenko, M. I. Lavrov, D. S. Karlov, Yu. K. Grishin, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina, V. A. Palyulin, “New nanomolar negative modulators of AMPA receptors”, Mendeleev Commun., 31:2 (2021), 219

Эта публикация цитируется в 4 статьях

Communications

New nanomolar negative modulators of AMPA receptors

N. S. Temnyakova^a, D. A. Vasilenko^a, M. I. Lavrov^ab, D. S. Karlov^a, Yu. K. Grishin^a, V. L. Zamoyski^b, V. V. Grigoriev^ab, E. B. Averina^ab, V. A. Palyulin^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Аннотация: Bisamides of 1,4-bis(aminomethyl)benzene with cyclopropane-, cyclobutane- and cyclopentanecarboxylic acids reveal the negative modulation of kainate-induced currents in rat Purkinje neurons observed using patch clamp technique. The most pronounced effect has been found for the bisamide of cyclobutanecarboxylic acid, which blocks the currents by 41 and 49% at concentrations of 1×10⁻¹⁰ and 1×10⁻⁹moldm⁻³, respectively.

Ключевые слова: AMPA receptor, negative modulator, patch clamp, Purkinje neurons, cycloalkanecarboxamide, 1,4-bis(aminomethyl)benzene.

Язык публикации: английский

DOI: 10.1016/j.mencom.2021.03.024

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