Keywords: heterocycles; targeted protein degradation, proteolysis-targeting chimeras, cereblon, linkers; 2-aminothiomorpholine-3,5-dione, halogenation; nucleophilic substitution reaction; cytotoxicity studies; immunomodulatory drugs; enediynes, propargylamines, 1,2,3-triazoles, benzothiophene, Sonogashira reaction, Mannich reaction

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• Institute of Chemistry, St. Petersburg State University
• K. D. Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russian Federation